RECHERCHE FONDAMENTALE - VIROLOGIE

Small RNA-Mediated Control of HIV-1 Transcription and its Role in Viral Latency
Jeunes Chercheurs

Dr Poornima BASAVARAJAIAH
Post-doctorant

Structure : CNRS UPR 1142 - Institut de Génétique Humaine (IGH)
MONTPELLIER
Responsable : Rosemary KIERNAN

RÉSUMÉ

A major obstacle preventing the eradication of HIV-1 from infected individuals is the reservoir of latently infected cells that are refractory to highly active therapy. Many of these cells contain integrated provirus that is transcriptionally silent. However, they can be re-activated under suitable conditions, and so re-seed the infected individual with virus. This vicious circle means that HAART is a lifelong therapy. Understanding the mechanisms that control transcriptional latency and re-activation is vital to achieving the goal of virus eradication.
This project aims to further study how the small HIV-1 RNA is able to repress viral transcription. A full understanding of how the small RNA shuts down viral transcription may provide the key to designing innovative new strategies to counteract its effect and reactivate latent virus.

MONTANT DE LA SUBVENTION :

86 942,64 € lors de l’Appel d’offres 2012 – Fin du contrat : 31/01/2015