RECHERCHE FONDAMENTALE - VIROLOGIE

Structural studies of the interaction between gC1qR and the ENV motif 3S
Jeunes Chercheurs

Dr Pablo GUARDADO CALVO
Post-doctorant

Structure : Département de Virologie - Virologie Structurale - CNRS UMR 3015 - Institut Pasteur
PARIS
Responsable : Felix REY

RÉSUMÉ

No vaccines are available against HIV in spite of intensive research over the years. Identifying ways of protecting against this deadly virus is therefore an important priority. The pathogenicity of HIV is related to a strong lymphopenia, that is, depletion of T lymphocytes in the infected patient. HIV is an enveloped virus, which means that it has a lipid bilayer surrounding the virus particle. To enter cells, it induces fusion of the viral membrane with the target cell membrane. HIV infects T cells and macrophages carrying the receptor CD4 (CD4+ T cells and MP). The entry process is mediated by the viral ENV protein complex, which upon interaction with entry receptors triggers fusion of the two membranes, thereby releasing the viral genome into the target cell. In this project, it propose to make structural studies of the 3S motif bound to its receptor gC1qR, and also bound to the various antibodies available in the Debré and Vieillard laboratory.

MONTANT DE LA SUBVENTION :

96 000 € lors de l’Appel d’offres 2012 – Fin du contrat : 28/11/2014